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Tottenham's title charge suffered a blow as they were beaten 3-1 by Wolves at Wembley.
Mauricio Pochettino's side overtook Manchester City to move into second place thanks to a 6-2 win against Everton and a 5-0 victory over Bournemouth.
But, after taking a 22nd minute lead through Harry Kane, they came undone thanks to three second-half goals.
Willy Boly headed Wolves level in the 72nd minute with a firm header before Raul Jimenez put them in front 10 minutes later with a low left-footed finish.